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self-reported smoking at least 10 manufactured combustible (menthol or non-menthol) cigarettes per day (CPD) for at least 12 months prior to screening

Spanish conquistadors documented this practice, making it one of the first written accounts of rolled cannabis

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Researchers also examined studies finding that vaping aerosols contain potentially carcinogenic compounds, including formaldehyde, acetaldehyde and heavy metals such as nickel, chromium and lead that may come from heating elements within devices